Publicações científicas

Efficacy of the Combination of Immunoadsorption and Rituximab for Treatment in a Case of Severe Focal and Segmental Glomerulosclerosis Recurrence after Renal Transplantation

Martin-Moreno PL (1), Rifon J (2), Errasti P (1).

(1) Department of Nephrology, Clinica Universidad de Navarra, Pamplona, Spain.
(2) Department of Hematology, Clinica Universidad de Navarra, Pamplona, Spain.

Revisão:Blood Purification

Data: 19/Abr/2018

Hematología y Hemoterapia [ES] Nefrologia [ES]

BACKGROUND/AIMS:

We present a case of a male patient with severe recurrence of focal and segmental glomerulosclerosis (FSGS) after transplant.

METHODS:

Before the transplant he was treated with plasma exchange. Massive proteinuria was detected post-transplantation and plasma exchanges were performed without response. We administered 5 doses of Rituximab (375 mg/m2) and partial remission was achieved. Proteinuria relapse occurred 1 year post-transplant, so Immunoadsorption (IA) was started instead of plasma exchange with reduction of proteinuria. Later, 2 new episodes of proteinuria relapse were detected and treated by increasing the number of IA sessions and administering new cycles of Rituximab. After achieving partial remission, IA was reduced to one session every 7-10 days as maintenance therapy.

RESULTS:

Despite the fact of the severe recurrence, renal function and proteinuria remain stable over 8 years after the transplantation was performed.

CONCLUSION:

Combination of maintenance IA and cycles of Rituximab is an effective treatment for aggressive forms of FSGS recurrence after renal transplantation.

CITAÇÃO DO ARTIGO  Blood Purif. 2018;46(2):90-93. doi: 10.1159/000488638. Epub 2018 Apr 19

talvezlhe interesse

QUE TECNOLOGIA UTILIZAMOS? 

A Clínica é o hospital privado com maiores recursos tecnológicos de Espanha, tudo num único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OS NOSSOS
PROFISSIONAIS

Os profissionais da Clínica realizam um trabalho contínuo de investigação e formação, sempre em benefício do paciente.

Imagen profesionales de la Clínica Universidad de Navarra

RAZÕES PARA VIR
À CLÍNICA

Conheça porque é que somos diferentes em relação a outros centros sanitários. Qualidade, rapidez, comodidade e resultados.

Imagen del edificio de la Clínica Universidad de Navarra