Publicações científicas

Arterial spin labelling MRI to measure renal perfusion: a systematic review and statement paper

Odudu A (1), Nery F (2), Harteveld AA (3), Evans RG (4), Pendse D (5), Buchanan CE (6), Francis ST (6), Fernández-Seara MA (7).

(1) Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
(2) Developmental Imaging & Biophysics Section, University College London, Great Ormond Street Institute of Child Health, London, UK.
(3) Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
(4) Department of Physiology, Cardiovascular Disease Program, Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia.
(5) Centre for Medical Imaging, University College London, London, UK.
(6) Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK.
(7) Department of Radiology, Clínica Universidad de Navarra, Navarra, Spain.

Revisão:Nephrology, Dialysis, Transplantation

Data: 1/Set/2018

Radiología [ES]

RESUMO

Renal perfusion provides the driving pressure for glomerular filtration and delivers the oxygen and nutrients to fuel solute reabsorption. Renal ischaemia is a major mechanism in acute kidney injury and may promote the progression of chronic kidney disease.

Thus, quantifying renal tissue perfusion is critically important for both clinicians and physiologists. Current reference techniques for assessing renal tissue perfusion have significant limitations.

Arterial spin labelling (ASL) is a magnetic resonance imaging (MRI) technique that uses magnetic labelling of water in arterial blood as an endogenous tracer to generate maps of absolute regional perfusion without requiring exogenous contrast.

The technique holds enormous potential for clinical use but remains restricted to research settings. This statement paper from the PARENCHIMA network briefly outlines the ASL technique and reviews renal perfusion data in 53 studies published in English through January 2018. Renal perfusion by ASL has been validated against reference methods and has good reproducibility. Renal perfusion by ASL reduces with age and excretory function. Technical advancements mean that a renal ASL study can acquire a whole kidney perfusion measurement in less than 5-10 min. The short acquisition time permits combination with other MRI techniques that might inform drug mechanisms and renal physiology.

The flexibility of renal ASL has yielded several variants of the technique, but there are limited data comparing these approaches. We make recommendations for acquiring and reporting renal ASL data and outline the knowledge gaps that future research should address.

CITAÇÃO DO ARTIGO  Nephrol Dial Transplant. 2018 Sep 1;33(suppl_2):ii15-ii21. doi: 10.1093/ndt/gfy180

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