Brain pathways of verbal working memory. A lesion function correlation study
Jorge Sepulcre (a,b), Joseph C. Masdeu (a,b,c,d,e), Maria A. Pastor (a,b,c), Joaquín Goñi (b), Carla Barbosa (a), Bartolomé Bejarano (a) and Pablo Villoslada (a,b,f)
(a) Department of Neurology and Neurosurgery, University of Navarra, Pamplona, Spain
(b) Department of Neuroscience, University of Navarra, Pamplona, Spain
(c) Neuroimaging Laboratory of the Center for Applied Medical Research, University of Navarra, Pamplona, Spain
(d) Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain
(e) Section on Integrative Neuroimaging (CBDB-NIMH), National Institutes of Health, Bethesda, MD, USA
(f) Department of Neurosciences, Institut d'investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain
Working memory relies on information processing by several well-identified gray matter regions. However, the white matter regions and pathways involved in this cognitive process remain unknown. An attractive and underexplored approach to study white matter connectivity in cognitive functions is through the use of non-aprioristic models, which specifically search disrupted white matter pathways.
For this purpose, we used voxel-based lesion-function mapping to correlate white matter lesions on the magnetic resonance images of 54 multiple sclerosis patients with their performance on a verbal working memory task. With this approach, we have identified critical white matter regions involved in verbal working memory in humans. They are located in the cingulum, parieto-frontal pathways and thalamo-cortical projections, with a left-sided predominance, as well as the right cerebellar white matter.
Our study provides direct evidence on the white matter pathways subserving verbal working memory in the human brain.
CITATION Neuroimage. 2009 Aug 15;47(2):773-8