Scientific publications

Waldenström macroglobulinemia associated with cutaneous lesions and type I cryoglobulinemia

Mar 1, 2008 | Magazine: Actas Dermo-Sifiliográficas

del Olmo J, España A, Idoate MA, Panizo C.
Departamento de Dermatología, Clínica Universitaria de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, España.


Waldenström macroglobulinemia is a blood dyscrasia characterized by monoclonal proliferation of B cells in the bone marrow, lymph nodes, and spleen. Patients with this disease show elevated serum levels and tissue deposition of monoclonal immunoglobulin (Ig) M produced by these aberrant cells.

We present the case of a patient with Waldenström macroglobulinemia who suffered cutaneous lesions resulting from deposition of k light chains of IgM and clinical manifestations secondary to associated type I cryoglobulinemia. We discuss the different pathological cutaneous processes caused by IgM in Waldenström macroglobulinemia.

CITATION  Actas Dermosifiliogr. 2008 Mar;99(2):138-44