Vitamin D and Age-Related Macular Degeneration
Layana AG (1), Minnella AM (2), Garhöfer G (3), Aslam T (4,5), Holz FG (6), Leys A (7), Silva R (8,9,10,11), Delcourt C (12), Souied E (13), Seddon JM (14,15).
In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities.
Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD.
Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.