Scientific publications

Using optical coherence tomography to monitor photodynamic therapy in age related macular degeneration

Jul 1, 2005 | Magazine: American Journal of Ophthalmology

Salinas-Alamán A, García-Layana A, Maldonado MJ, Sainz-Gómez C, Alvárez-Vidal A.


PURPOSE
To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularization (CNV) activity before and after photodynamic therapy (PDT) in patients with age-related macular degeneration (ARMD).

DESIGN
Prospective observational case series.

SETTING
Institutional study. patient population: Fifty-three patients (62 eyes) with ARMD.

OBSERVATION PROCEDURE
Prospective observational case study.

MAIN OUTCOME MEASURES
Presence or absence of leakage on fluorescein angiography, presence of intraretinal or sub-retinal fluid on OCT, and macular and choroidal neovascular complex thickness on OCT. RESULTS: The macular thickness decreased significantly after PDT (P = .001). However, no significant changes in CNV thickness were measured after PDT (P = .567). Once the diagnosis of ARMD was established before treatment, OCT had a sensitivity of 96.77% for detecting CNV activity. After treatment, OCT had a good sensitivity (95.65%) and a moderate specificity (59.01%) in determining CNV activity, which resulted in a diagnostic efficiency (proportion of correct results) of 82.95%.

CONCLUSIONS
OCT appears to be useful for indicating CNV activity. Therefore, it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with ARMD.

CITATION  Am J Ophthalmol. 2005 Jul;140(1):23-8.  doi: 10.1016/j.ajo.2005.01.044.