Scientific publications

Towards an adiposity-related disease framework for the diagnosis and management of obesities

May 10, 2023 | Magazine: Reviews in Endocrine & Metabolism Disorders

Carolina M Perdomo  1   2   3 , Icíar Avilés-Olmos  2   4 , Dror Dicker  5   6 , Gema Frühbeck  7   8   9


Obesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others.

Noteworthy, excess adiposity is accompanied by chronic inflammation, oxidative stress, insulin resistance, and subsequent organ dysfunction. This dysfunctional adipose tissue is initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity in ectopic depots like liver, heart, muscle, and pancreas, among others.

People living with obesity need a diagnostic approach that considers an exhaustive pathophysiology and complications assessment. Thus, it is essential to warrant a holistic diagnosis and management that guarantees an adequate health status, and quality of life.

The present review summarizes the different complications associated with obesity, at the same time, we aim to fostering a novel framework that enhances a patient-centered approach to obesity management in the precision medicine era.

CITATION  Rev Endocr Metab Disord. 2023 May 10. doi: 10.1007/s11154-023-09797-2.