Scientific publications 

Therapeutic illusion: another frontier in Ménière's disease

Pérez-Fernández N (1), Martín-Sanz E (2).
(1) Department of Otorhinolaryngology, Clinica Universidad de Navarra, University of Navarra, Navarra, Spain.
(2) Department of Otolaryngology, University Hospital of Getafe, European University of Madrid, Madrid, Spain. 

Magazine: Annals of Translational Medicine

Date: Oct 1, 2016

Otorhinolaryngology Department [SP]

Idiopathic endolymphatic hydrops, often referred as Ménière’s disease (MD) is characterized by episodes of vertigo, hearing loss, tinnitus, and aural fullness (1,2). It is often a challenge in diagnosis and description, mostly because of its variability, which can make it difficult to recognize, thus possibly delaying treatment (3).

Hearing loss has been widely studied, a fact that inclusively supports its staging according to the different guidelines proposed (4). Vertigo attacks appear to be the factor that affects more the health related quality of life of these patients as such, the primary goal of treatment is to reduce the frequency, intensity and duration of these episodes (1,5).

There are several difficulties, any author must stand, when analyzing results obtained with any MD treatment proposed. Fluctuation nature of the disease, the high and unexpected spontaneous remission rate, the difficulty of including a control group of patients without any intervention and the lack of validated instruments related to vertigo outcomes (other than disability and quality of life measurements) are clear examples of such problems. Here lies the importance of an appropriate clinical trial design, in order to prevent those possible methodological errors. 

CITATION  Ann Transl Med. 2016 Oct;4(Suppl 1):S63.

you maybe interested


The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra


Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra