Scientific publications 

The Gain-Time Constant Product Quantifies Total Vestibular Output in Bilateral Vestibular Loss

Hain TC (1,2), Cherchi M (1,2), Perez-Fernandez N (3).

(1) Chicago Dizziness and Hearing, Chicago, IL, United States.
(2) Department of Neurology, Northwestern University, Chicago, IL, United States.
(3) Department of Otorhinolaryngology, Clinica Universidad de Navarra, Madrid, Spain.

Magazine: Frontiers in Neurology

Date: Jun 11, 2018

Otorhinolaryngology Department [SP]


Patients with inner ear damage associated with bilateral vestibular impairment often ask "how much damage do I have." Although there are presently three clinical methods of measuring semicircular canal vestibular function; electronystagmography (ENG or VENG), rotatory chair and video head-impulse (VHIT) testing; none of these methods provides a method of measuring total vestibular output.

Theory suggests that the slow cumulative eye position can be derived from the rotatory chair test by multiplying the high frequency gain by the time constant, or the "GainTc product." In this retrospective study, we compared the GainTc in three groups, 30 normal subjects, 25 patients with surgically induced unilateral vestibular loss, and 24 patients with absent or nearly absent vestibular responses due to gentamicin exposure.

We found that the GainTc product correlated better with remaining vestibular function than either the gain or the time constant alone. The fraction of remaining vestibular function was predicted by the equation R = (GainTc/11.3) - 0.6.

We suggest that the GainTc product answers the question "how much damage do I have," and is a better measure than other clinical tests of vestibular function.

CITATION  Front Neurol. 2018 Jun 11;9:396. doi: 10.3389/fneur.2018.00396. eCollection 2018

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