Scientific publications

The antihypertensive efficacy and tolerance of bopindolol (LT 31-200) in hypertensive patients

Honorato J, Galende I, Catalán M, Azanza JR.
Servicio de Farmacología Clínica, Clínica Universitaria de Navarra.

Magazine: Revista de Medicina de la Universidad de Navarra

Date: May 1, 1990

Clinical Pharmacology [SP]


A open study with increasing doses of bopindolol, a nonselective beta-blocker of long half-life has been carried out in patients with mild and moderate hypertension in order to assess the efficacy and security of the treatment in short and long term.

Twenty patients (22 women and 8 men) were included with the ranging ages from 36 to 62 years old (x +/- SD 51.6 +/- 7.6) whose blood pressures were higher than 160 mm Hg for the systolic value and between 90 and 125 mm Hg for the diastolic (x +/- SD 165 +/- 7.2 and 102.6 +/- 6.7 respectively). Nineteen from the twenty patients (95%) responded satisfactorily after 20 weeks of oral bopindolol treatment once a day showing significative statistical differences on forth week of the treatment versus blood pressure rates of placebo's period.

Similar results were obtained with regard to the cardiac frequency. HDL cholesterol rates increased significantly as well as the ratio HDL cholesterol/total cholesterol.

CITATION  Rev Med Univ Navarra. 1990 Apr-Jun;34(2):90-4

you maybe interested


The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra


Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra