Scientific publications
Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry
Merola A (1), Fasano A (2,3), Hassan A (4), Ostrem JL (5), Contarino MF (6,7,8), Lyons M (9), Krauss JK (10), Wolf ME (11), Klassen BT (4), van Rootselaar AF (6), Regidor I (12), Duker AP (1), Ondo W (13), Guridi J (14), Volkmann J (15), Shukla AW (16), Mandybur GT (17), Okun MS (16), Witt K (18,19), Starr PA (20), Deuschl G (18), Espay AJ (1).
BACKGROUND:
We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor.
METHODS:
Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (≥48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications.
RESULTS:
There was a 21.6% improvement (P = 0.004) in the composite activities of daily living/instrumental activities of daily living score, which gradually attenuated (12.5%) in the subgroup of patients with an additional long-term follow-up (8 of 17). The latency of symptoms on standing significantly improved, both in the short-term (P = 0.001) and in the long-term (P = 0.018). Three patients obtained no/minimal benefit from the procedure.
CONCLUSIONS:
Deep brain stimulation of the ventral intermediate nucleus was, in general, safe and well tolerated, yielding sustained benefit in selected patients with medically refractory orthostatic tremor. © 2017 International Parkinson and Movement Disorder Society.
CITATION Mov Disord. 2017 Jun 20. doi: 10.1002/mds.27082