Scientific publications

Takotsubo cardiomyopathy secondary to electroconvulsive therapy in a young adult with Down syndrome regression disorder

Dec 1, 2023 | Magazine: American Journal of Medical Genetics

María Del Carmen Ortega  1 , José Pablo Bullard  2 , María Del Mar Unceta  2 , Felipe Ortuño Sánchez-Pedreño  2   3 , Patricio Molero  2   3 , Diego Real de Asúa  4


We report the case of an 18-year-old woman with Down syndrome (DS) who developed Takotsubo cardiomyopathy (TSC) immediately after the administration of electroconvulsive therapy (ECT), a treatment prescribed for Down syndrome regression disorder resistant to oral psychotropic drugs.

TSC is a nonischemic cardiomyopathy related to psychological or physical stress, which has been described as a rare complication of ECT (Kinoshita et al., 2023, Journal of Electroconvulsive Therapy, 39, 185-192).

The clinical description of the case is accompanied by a discussion of the peculiarities of the autonomic nervous system in DS.

CITATION  Am J Med Genet C Semin Med Genet . 2023 Dec 1:e32078. doi: 10.1002/ajmg.c.32078