Successful desensitization in a child with delayed cotrimoxazole hypersensitivity: A case report
Carmen M D'Amelio 1 , José L Del Pozo 2 , Olga Vega 3 , Roselle Madamba 3 , Gabriel Gastaminza 3
To the Editor:
Sulfonamides are effective drugs for the treatment of infectious diseases caused by a number of pathogens including Gram-positive bacteria, Gram-negative bacteria, and protozoa.
The probability of severe allergic reactions to this group of drugs and the development of different families of antimicrobials have caused a limited usage to a few specific indications in certain groups of patients.
Trimethoprim is a bacteriostatic agent which is commonly used in combination with sulfamethoxazole due to their synergic effect, known as cotrimoxazole. Several allergic reactions to cotrimoxazole, ranging from mild to potentially fatal syndromes such as Steven Johnson's or toxic epidermal necrolysis, have been described 1. According to literature, sulfamethoxazole is the culprit of most of the allergic reactions induced by the association of trimethoprim–sulfamethoxazole 2.
CITATION Pediatr Allergy Immunol. 2016 May;27(3):320-1. doi: 10.1111/pai.12525. Epub 2016 Feb 5.