Study of HLA antigens in patients with osteosarcoma
Barona P, Sierrasesúmaga L, Antillón F, Villa-Elízaga I.
Department of Pediatrics, Universitary Clinic, School of Medicine, University of Navarra, Pamplona, Spain
HLA typing was carried out in a group of twenty-four Spanish unrelated patients diagnosed with conventional high-grade osteosarcoma.
All of them were typed for HLA-A and HLA-B antigens. A significant increase in the HLA-A11 (33.3 vs. 12%, chi 2 = 9.752, corrected p value = 0.016) and HLA-B7 (33.3 vs. 11.3%, chi 2 = 10.919, corrected p value = 0.011) was found in osteosarcoma patients compared with the control group. A trend towards an increased frequency in HLA-A24 and HLA-A28 antigens was also found.
CITATION Hum Hered. 1993 Sep-Oct;43(5):311-4