Scientific publications

Simple automated system for simultaneous production of 11C-labeled tracers by solid supported methylation

Jul 1, 2006 | Magazine: Applied Radiation and Isotopes

Quincoces G, Peñuelas I, Valero M, Serra P, Collantes M, Martí-Climent J, Arbizu J, García-Velloso MJ, Richter JA.

We herein describe a simple setup for the automated simultaneous synthesis of L-[methyl-11C]methionine and N-[methyl-11C]choline by solid-supported methylation.

The setup is extremely simple and easy to adapt to other automated systems and due to its versatility, the method can be utilized for the production of other radiopharmaceuticals requiring a simple [11C]methylation step. Furthermore, it can be used for multiple simultaneous synthesis.

CITATION  Appl Radiat Isot. 2006 Jul;64(7):808-11

see publication in pubmed

Our authors

Imagen de la Dra. Gemma Quincoces Fernandez. Radiofarmacia. Clínica Universidad de Navarra
Dr. Gemma Quincoces Fernández [SP] Curriculum
Radiopharmaceutical Nuclear Medicine Department
Navarre headquarters
Imagen del Dr. Ivan Peñuelas Sanchez. Radiofarmacia. Clínica Universidad de Navarra
Dr. Iván Peñuelas Sánchez [SP] Curriculum
Director Radiopharmacy unit
Navarre headquarters
Imagen Dr. Josep Marti Climent, Departamento de Medicina Nuclear.
Dr. Josep Martí Climent [SP] Curriculum
Director Radiophysics and Radiological Protection Services
Navarre headquarters
Imagen Dr. Javier Arbizu Lostao, Departamento de Medicina Nuclear.
Dr. Javier Arbizu Lostao [SP] Curriculum
Director Nuclear Medicine Department
Navarre headquarters
Imagen Dra. Maria Jose Garcia Velloso, Departamento de Medicina Nuclear.
Dr. Mª José García Velloso [SP] Curriculum
Specialist Nuclear Medicine Department
Navarre headquarters