This paper reviews working procedures for the analytical determination of camptothecin and analogues. We give an overview of aspects such as the chemistry, structure-activity relationships, stability and mechanism of action of these antitumor compounds.
The main body of the review describes separation techniques. Sample treatment and factors influencing high-performance liquid chromatography development are delineated.
Published high-performance liquid chromatographic methods are summarized to demonstrate the variability and versatility of separation techniques and a critical evaluation of separation efficiency, detection sensitivity and specificity of these methods is reported.
CITATION J Chromatogr B Biomed Sci Appl. 2001 Nov 25;764(1-2):141-9
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