Scientific publications

Safety of allogeneic blood transfusion alternatives in the surgical/critically ill patient

Jul 14, 2015 | Magazine: Medicina Intensiva

Muñoz Gómez M(1), Bisbe Vives E(2), Basora Macaya M(3), García Erce JA(4), Gómez Luque A(5), Leal-Noval SR(6), Colomina MJ(7), Comin Colet J(8), Contreras Barbeta E(9), Cuenca Espiérrez J(10), Garcia de Lorenzo Y Mateos A(11), Gomollón García F(12), Izuel Ramí M(13), Moral García MV(14), Montoro Ronsano JB(15), Páramo Fernández JA(16), Pereira Saavedra A(17), Quintana Diaz M(11), Remacha Sevilla Á(18), Salinas Argente R(19), Sánchez Pérez C(20), Tirado Anglés G(21), Torrabadella de Reinoso P(22).


In recent years, several safety alerts have questioned or restricted the use of some pharmacological alternatives to allogeneic blood transfusion in established indications. In contrast, there seems to be a promotion of other alternatives, based on blood products and/or antifibrinolytic drugs, which lack a solid scientific basis.

The Multidisciplinary Autotransfusion Study Group and the Anemia Working Group España convened a multidisciplinary panel of 23 experts belonging to different healthcare areas in a forum for debate to: 1) analyze the different safety alerts referred to certain transfusion alternatives; 2) study the background leading to such alternatives, the evidence supporting them, and their consequences for everyday clinical practice, and 3) issue a weighted statement on the safety of each questioned transfusion alternative, according to its clinical use. The members of the forum maintained telematics contact for the exchange of information and the distribution of tasks, and a joint meeting was held where the conclusions on each of the items examined were presented and discussed.

A first version of the document was drafted, and subjected to 4 rounds of review and updating until consensus was reached (unanimously in most cases). We present the final version of the document, approved by all panel members, and hope it will be useful for our colleagues.

CITATION  Med Intensiva. 2015 Jul 14. pii: S0210-5691(15)00117-5. doi: 10.1016/j.medin.2015.05.006.

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