Scientific publications

Risk of unintentional injuries in children and adolescents with ADHD and the impact of ADHD medications

Ruiz-Goikoetxea M (1), Cortese S (2), Aznarez-Sanado M (3), Magallón S (4), Zallo NA (5), Luis EO (6), de Castro-Manglano P (7), Soutullo C (8), Arrondo G (9).

(1) Servicio de Urgencias Extrahospitalarias Servicio Navarro de Salud-Osasunbidea, Pamplona, Spain.
(2) Center for Innovation in Mental Health, University of Southampton, Academic Unit of Psychology, Southampton, UK; Faculty of Medicine, Clinical and Experimental Sciences (CNS and Psychiatry), University of Southampton, Southampton, UK; Department of Child and Adolescent Psychiatry, NYU Langone Medical Center, New York, NY, USA.
(3) Facultad de Educación y Psicología, Universidad de Navarra, Pamplona, Spain.
(4) Facultad de Educación y Psicología, Universidad de Navarra, Pamplona, Spain.
(5) Servicio de Urgencias Extrahospitalarias Servicio Navarro de Salud-Osasunbidea, Pamplona, Spain.
(6) Facultad de Educación y Psicología, Universidad de Navarra, Pamplona, Spain.
(7) Departamento de Psiquiatría y Psicología Médica, Unidad de Psiquiatría Infantil y Adolescente, Clínica Universidad de Navarra, Pamplona, Spain.
(8) Departamento de Psiquiatría y Psicología Médica, Unidad de Psiquiatría Infantil y Adolescente, Clínica Universidad de Navarra, Pamplona, Spain.
(9) Instituto Cultura y Sociedad (ICS), Grupo Mente-Cerebro, Universidad de Navarra, Pamplona, Spain

Magazine: Neuroscience and Biobehavioral Reviews

Date: Nov 18, 2017

Psychiatry and Clinical Psychology [SP]

ABSTRACT

A systematic review with meta-analyses was performed to: 1) quantify the association between ADHD and risk of unintentional physical injuries in children/adolescents ("risk analysis"); 2) assess the effect of ADHD medications on this risk ("medication analysis").

We searched 114 databases through June 2017. For the risk analysis, studies reporting sex-controlled odds ratios (ORs) or hazard ratios (HRs) estimating the association between ADHD and injuries were combined. Pooled ORs (28 studies, 4,055,620 individuals without and 350,938 with ADHD) and HRs (4 studies, 901,891 individuals without and 20,363 with ADHD) were 1.53 (95% CI=1.40,1.67) and 1.39 (95% CI=1.06,1.83), respectively.

For the medication analysis, we meta-analysed studies that avoided the confounding-by-indication bias [four studies with a self-controlled methodology and another comparing risk over time and groups (a "difference in differences" methodology)].

The pooled effect size was 0.879 (95% CI=0.838,0.922) (13,254 individuals with ADHD). ADHD is significantly associated with an increased risk of unintentional injuries and ADHD medications have a protective effect, at least in the short term, as indicated by self-controlled studies.

CITATION  Neurosci Biobehav Rev. 2017 Nov 18. pii: S0149-7634(17)30672-3. doi: 10.1016/j.neubiorev.2017.11.007

you maybe interested

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra