Respiratory effects of nicotine and naloxone
Jiménez-Vargas J, Fernández-González S, Dawid-Milner S.
Dpto. de Fisiologia, Facultad de Medicina, Universidad de Navarra, Pamplona.
The effect of an i.v. bolus injection of nicotine 50 micrograms/kg-1, was compared in 6 awake dogs with the effect of nicotine injection after naloxone, 400 micrograms/kg-1. Respiratory inhibition was produced immediately after beginning the nicotine injection, followed by hyperpnea.
Naloxone produced a significant decrease of the respiratory inhibition followed by hyperpnea increase compared to the trial with only nicotine.
CITATION Rev Med Univ Navarra. 1988 Jan-Mar;32(1):51-2