Prognostic value of local vascular infiltration in infiltrating transitional carcinoma of the bladder
de Castro F, Sánchez P, Robledo C, Rosell D, Agüera L, Isa W, Robles JE, Berián JM.
Departamento de Urología, Facultad de Medicina, Universidad de Navarra
The present retrospective study analyzes the evolution and survival of 79 patients with bladder infiltrant transitional carcinoma (T2-T3), which were treated with radical cystectomy and bilateral ilio-obturating lymphadenectomy. Pre-operative radiotherapy (57/79) and neo-adjuvant chemotherapy (24/79) was used as supplementary therapy.
The univariate analysis showed the relationship between tumour vascular infiltration (TVI) and presence of nodes micrometastasis (p = 0.002). The variables with greater forecast power in the multivariate analysis for survival were a decline in the post-radio and/or neo-adjuvant chemotherapy tumoral stage (p = 0.000) and TVI (p = 0.001).
Survival decreased significantly in patients with TVI (p = 0.008), this finding denoting a worse prognosis than the presence of nodular micrometastasis (p = 0.01).
CITATION Actas Urol Esp. 1992 Apr;16(4):321-4