Platelet dysfunction in cardiopulmonary bypass: an experimental comparative study between a centrifugal and a new pulsatile pump
Herreros J., Berjano E.J., Más P., Padrós C., Sales-Nebot L., Vlaanderen W., Díaz P., Páramo J.A., Rábago G., Mercé S.
Cardiovascular Surgery Department, Clínica Universitaria, University of Navarra, Pamplona, Spain
Magazine: The International Journal of Artificial Organs
Date: Aug 1, 2003Hematología y Hemoterapia [SP] Cardiac Surgery [SP]
The aim of this investigation was to study the effect of a new pulsatile pump for extracorporeal circulation (ECC) on platelet count and platelet function with respect to a Biomedicus centrifugal pump. Thirteen pigs, 8 in the pulsatile group (PG) and 5 in the centrifugal group (CG), underwent a partial extracorporeal circulation lasting 3 h. The animals were sacrificed 3 h post-ECC.
The platelet study was both quantitative (platelet count) and qualitative (platelet function analysis) by assessing the closure time (CT) with a PFA-100 system. The decrease in platelet number from basal to 3 h post ECC was only significant in CG (p = 0.009). The platelet function was impaired in both groups, but the value of CT with col/ADP increased significantly only in CG (p < 0.001). The increase of CT with col/EPI was greater in CG (p = 0.07) than in PG (p = 0.2).
The results indicated that the new pulsatile pump preserves platelets quantitatively and qualitatively well compared to a Biomedicus pump.
CITATION Int J Artif Organs. 2003 Dec;26(12):1086-94
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