Scientific publications

Photo-induced toxic epidermal necrolysis caused by clobazam

Dec 1, 1996 | Magazine: The British Journal of Dermatology

Redondo P, Vicente J, España A, Subira ML, De Felipe I, Quintanilla E.
Department of Dermatology, University Clinic of Navarra, School of Medicine, Pamplona, Spain


Toxic epidermal necrolysis (TEN) is a life-threatening disease, the pathogenesis of which remains largely unknown. We describe a 23-year-old woman under treatment with clobazam who developed lesions of TEN in light-exposed areas. Patch and photopatch tests with clobazam were negative. The cellular phenotype and cytokines were studied in blister fluid. The cellular infiltrate was composed mainly of T lymphocytes with a predominant cytotoxic phenotype.

There was an increase in the level of tumour necrosis factor (TNF)-alpha in blister fluid compared with the control (a patient with bullous pemphigoid).

CITATION Br J Dermatol. 1996 Dec;135(6):999-1002