Scientific publications

Pediatric bipolar disorder in a Spanish sample: Features before and at the time of diagnosis

Mar 11, 2009 | Magazine: Journal of Affective Disorders

Cesar A. Soutullo (a), Inmaculada Escamilla-Canales (b), Janet Wozniak (c), Pilar Gamazo-Garrán (b), Ana Figueroa-Quintana (a) and Joseph Biederman (c) 
(a) Child & Adolescent Psychiatry Unit, Department of Psychiatry & Medical Psychology, Clínica Universitaria, University of Navarra, Pamplona, Spain
(b)Child & Adolescent Psychiatry Unit, Department of Psychiatry & Medical Psychology, Clínica Universitaria (Madrid Campus), University of Navarra, Madrid, Spain
(c)Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

Bipolar disorder (BD) often starts in childhood or adolescence. Diagnostic delay is common and may have a negative impact on treatment response and outcome.

To describe the clinical characteristics and symptoms of children with BD prior to their diagnosis and at the time of diagnosis in a sample in Spain.

We retrospectively reviewed the medical records of all children and adolescents (N = 38) with a DSM-IV diagnosis of BD evaluated in the Child & Adolescent Psychiatry Unit, University of Navarra, over a 6-year period. We collected the DSM-IV symptoms of BD prior and at the time of diagnosis using the K-SADS-PL interview template.

BD was diagnosed in close to 4% of clinic patients. Thirty (79%) were boys and 8 (21%) were girls; 17 (44.7%) had BD-1, 2 (5.3%) BD-2, and 19 (49.9%) BD-NOS. Median age at diagnosis was 13.9 (10.6;15.9). Delay of diagnosis was 1.5 (0.7;3.4) years. Symptoms of BD were similar to those reported in U.S. samples with high rates of severe irritability (94.6%) and psychiatric comorbidity: 92.1% of the BD children had at least one comorbid disorder and 18.4% had three comorbidities, most frequently ADHD (21%) and substance abuse (18.4%).

Clinical findings in this Spanish sample of children with BD closely resembles those described in U.S. clinics. Diagnostic delay, as in the U.S., and frequent misdiagnosis may explain low prevalence estimates found outside the U.S.

CITATION  J Affect Disord. 2009 Nov;118(1-3):39-47