Patterns of failure and long-term results in high-risk resected gastric cancer treated with postoperative radiotherapy with or without intraoperative electron boost
Martínez-Monge R. (1), Calvo F.A. (1), Azinovic I. (1), Aristu J.J. (1), Hernández J.L. (2), Pardo F. (2), Fernández P. (3), García-Foncillas J. (1), Álvarez-Cienfuegos J. (2)
(1) Department of Oncology, Clínica Universitaria de Navarra, Pamplona, Spain
(2) Department of Surgery, Clínica Universitaria de Navarra, Pamplona, Spain
(3) Instituto Oncológico de San Sebastián, San Sebastián, Spain
To evaluate the possible role of adjuvant radiotherapy in the management of high-risk resected gastric carcinoma.
From 1982 to 1993, 62 patients surgically resected of a primary gastric cancer with adverse pathological features (serosal and/or regional lymph node involvement) were treated with postoperative radiotherapy with (Group I) or without (Group II) intraoperative electron boost to the surgical bed and coeliac axis (IORT).
After a median follow-up of 75.6 months (range 4-120+) for IORT patients and 91.2 months (range 6-149+) for non-IORT patients, overall relapse rates for Group I and Group II patients were 44.5% and 48.6% and local-regional relapse rates were 11.1% and 20%, respectively. Actuarial survival rates projected at the maximum follow-up were 41% and 38% in Groups I and II, respectively.
This retrospective analysis suggests a beneficial effect of adjuvant external radiotherapy in promoting local-regional control in high-risk resected gastric cancer.
CITATION J Surg Oncol. 1997 Sep;66(1):24-9