Scientific publications

Oncogenes in Cancer: Using the Problem as Part of the Solution

Nov 18, 2020 | Magazine: Cancers (Basel)

Ignacio Gil-Bazo

Human cancer is considered to have a multifactorial origin. The exposure to certain environmental, occupational or social carcinogens such as ultraviolet irradiation [1], asbestos [2,3], radon [3] or tobacco [2], among others, is well documented to increase the individual risk of developing a number of neoplasms. In addition, a growing concern is infection by specific viruses (EBV [4], VIH [5], HPV [6], HCV [7]…) as other sources of cancer-related factors.

However, human malignancies have also been considered a genomic condition [8]. In fact, genome instability and mutations are one of the well-recognized hallmarks of cancer [9]. More specifically, a large number of hereditary cancer syndromes can cause a higher individual predisposition to develop cancer [10]. Most of these syndromes are generated by germline mutations in cancer suppressor genes, and they may cause the appearance of different tumor types. Overall, it is estimated that up to 10% of all new cancer cases are attributed to inherited genetic alterations [10].

CITATION  Cancers (Basel). 2020 Nov 14;12(11):E3373.  doi: 10.3390/cancers12113373