Scientific publications

Obsessive-compulsive disorder secondary to brain dysgerminoma in an adolescent boy: a positron emission tomography case report

Gamazo-Garrán P, Soutullo CA, Ortuño F.
Department of Psychiatry and Medical Psychology, Clínica Universitaria, University of Navarra College of Medicine, Pamplona, Spain.

Magazine: Journal of Child and Adolescent Psychopharmacology

Date: Jun 1, 2002

Child and Adolescent Psychiatry Unit [SP] Psychiatry and Clinical Psychology [SP]


The neuroanatomical model involved in the pathophysiology of obsessive-compulsive disorder (OCD) postulates a hyperactivation of orbitofrontal, limbic, and basal ganglia circuits. We report a case of OCD secondary to brain dysgerminoma affecting this circuit in an adolescent who responded to citalopram.

The patient is a 16-year-old-boy with a midline germinal tumor (dysgerminoma) affecting the caudate nuclei; left lenticular, right internal capsule's genu; and bilateral involvement of the interventricular septum close to the interventricular foramina. He had OCD symptoms and elevated tumor markers when he had a tumor relapse, and fluorodeoxyglucose positron emission tomography showed caudate nuclei involvement.

He responded to citalopram that had to be titrated gradually to 80 mg/day.

CITATION  J Child Adolesc Psychopharmacol. 2002 Fall;12(3):259-63

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