Scientific publications

Obsessive-compulsive disorder secondary to brain dysgerminoma in an adolescent boy: a positron emission tomography case report

Jun 1, 2002 | Magazine: Journal of Child and Adolescent Psychopharmacology

Gamazo-Garrán P, Soutullo CA, Ortuño F.


The neuroanatomical model involved in the pathophysiology of obsessive-compulsive disorder (OCD) postulates a hyperactivation of orbitofrontal, limbic, and basal ganglia circuits. We report a case of OCD secondary to brain dysgerminoma affecting this circuit in an adolescent who responded to citalopram.

The patient is a 16-year-old-boy with a midline germinal tumor (dysgerminoma) affecting the caudate nuclei; left lenticular, right internal capsule's genu; and bilateral involvement of the interventricular septum close to the interventricular foramina. He had OCD symptoms and elevated tumor markers when he had a tumor relapse, and fluorodeoxyglucose positron emission tomography showed caudate nuclei involvement.

He responded to citalopram that had to be titrated gradually to 80 mg/day.

CITATION  J Child Adolesc Psychopharmacol. Fall 2002;12(3):259-63. doi: 10.1089/104454602760386950.