Scientific publications

Obsessive-compulsive disorder secondary to brain dysgerminoma in an adolescent boy: a positron emission tomography case report

Jun 1, 2002 | Magazine: Journal of Child and Adolescent Psychopharmacology

Gamazo-Garrán P, Soutullo CA, Ortuño F.
Department of Psychiatry and Medical Psychology, Clínica Universitaria, University of Navarra College of Medicine, Pamplona, Spain.


The neuroanatomical model involved in the pathophysiology of obsessive-compulsive disorder (OCD) postulates a hyperactivation of orbitofrontal, limbic, and basal ganglia circuits. We report a case of OCD secondary to brain dysgerminoma affecting this circuit in an adolescent who responded to citalopram.

The patient is a 16-year-old-boy with a midline germinal tumor (dysgerminoma) affecting the caudate nuclei; left lenticular, right internal capsule's genu; and bilateral involvement of the interventricular septum close to the interventricular foramina. He had OCD symptoms and elevated tumor markers when he had a tumor relapse, and fluorodeoxyglucose positron emission tomography showed caudate nuclei involvement.

He responded to citalopram that had to be titrated gradually to 80 mg/day.

CITATION  J Child Adolesc Psychopharmacol. 2002 Fall;12(3):259-63