Scientific publications

NUM-score: A clinical-analytical model for personalised imaging after urinary tract infections

Mar 1, 2024 | Magazine: Acta Paediatrica

Isabel González-Bertolín  1 , Guillermo Barbas Bernardos  2 , Alejandro Zarauza Santoveña  3 , Leire García Suarez  3   4 , Rosario López López  1 , Marta Plata Gallardo  1   5 , Cristina De Miguel Cáceres  1   5 , Cristina Calvo  6

Aim: To identify predictive variables and construct a predictive model along with a decision algorithm to identify nephrourological malformations (NUM) in children with febrile urinary tract infections (fUTI), enhancing the efficiency of imaging diagnostics.

Methods: We performed a retrospective study of patients aged <16 years with fUTI at the Emergency Department with subsequent microbiological confirmation between 2014 and 2020. The follow-up period was at least 2 years. Patients were categorised into two groups: 'NUM' with previously known nephrourological anomalies or those diagnosed during the follow-up and 'Non-NUM' group.

Results: Out of 836 eligible patients, 26.8% had underlying NUMs. The study identified six key risk factors: recurrent UTIs, non-Escherichia coli infection, moderate acute kidney injury, procalcitonin levels >2 μg/L, age <3 months at the first UTI and fUTIs beyond 24 months. These risk factors were used to develop a predictive model with an 80.7% accuracy rate and elaborate a NUM-score classifying patients into low, moderate and high-risk groups, with a 10%, 35% and 93% prevalence of NUM. We propose an algorithm for approaching imaging tests following a fUTI.

Conclusion: Our predictive score may help physicians decide about imaging tests. However, prospective validation of the model will be necessary before its application in daily clinical practice.

CITATION  Acta Paediatr. 2024 Mar 1. doi: 10.1111/apa.17191