New era in antiplatelet therapy based on results from recent clinical trials
Servicio de Hematología, Clínica Universidad de Navarra, Pamplona, Navarra, España
Antiplatelet therapy has been successful in reducing mortality and morbidity in cardiovascular diseases (e.g. acute coronary syndromes). Recent advances in understanding the molecular basis of the role of platelets in atherothrombosis have enabled the development of new agents with the potential to further reduce mortality and morbidity.
Some limitations associated with the use of aspirin and clopidogrel have led to potential alternatives, including more potent ADP antagonists such as prasugrel, ticagrelor, cangrelor, and thrombin receptor antagonists, which have shown additional benefit in large randomized controlled trials.
These new agents open a realistic prospect of a personalized choice of the most appropriate antiplatelet therapy tailored for an individual patient and a clinical condition.
CITATION Med Clin (Barc). 2011 Oct 22;137(11):504-8. Epub 2010 Nov 13