Neurotoxic effect of prenatal exposure to MPTP on the dopaminergic systems of the marmoset brain
Pérez-Otaño I, Oset C, Trinidad Herrero M, Luquin MR, Kupsch A, Oertel W, Obeso JA, Del Río J.
Department of Pharmacology, University of Navarra Medical School, Pamplona, Spain
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was incidentally administered to pregnant marmosets during the whole gestational period, except for the last 15 days before term. The infant monkeys were killed 5 months after birth, and dopamine and its metabolites were measured in the striatum and the nucleus accumbens.
Prenatal exposure to MPTP produced a marked dopamine depletion in these brain regions of the offspring, showing that MPTP is able to cross the placental barrier in primates.
CITATION Eur J Pharmacol. 1992 Jul 7;217(2-3):211-3