Nasal Delivery Devices: A Comparative Study on Cadaver Model
Moffa A (1), Costantino A (2), Rinaldi V (2), Sabatino L (2), Trecca EMC (1), Baptista P (3), Campisi P (4), Cassano M (1), Casale M (2).
(1) Unit of Otolaryngology, University of Foggia, Foggia, Italy.
(2) Unit of Otolaryngology, UOS ORL TI, Campus Bio-Medico University, Rome, Italy.
(3) Unit of Otolaryngology, Clinica Universitaria de Navarra, Pamplona, Spain.
(4) Department of Otolaryngology-Head and Neck Surgery, University of Toronto, 190 Elizabeth Street 3S-438, Toronto M5G 2C4, Canada.
Nasal nebulization is a more effective method of delivering topical medication than nasal spray.
The purpose of this study was to assess the deposition patterns of nebulization in delivering topical agents to the nasal cavities in the human cadaveric model using a color-based method. We have compared these following nasal devices: single-dose vial irrigation, syringe-irrigation, common nasal spray, Spray-sol, MAD nasal, and Rinowash nasal douche.
Endoscopic images were recorded at six anatomical regions prior to and following each nasal device application and four reviewers evaluated the amount of surface area staining. At the nasal vestibule, the blue dye distribution achieved with Spray-sol was more extensive than nasal sprays. At inferior turbinate and nasal cavity floor, single dose vial, syringe, MAD nasal, Spray-sol, and Rinowash demonstrated a greater extent of dye distribution than nasal spray.
At the middle turbinate, the average score of both Spray-sol and MAD nasal was significantly higher than other nasal investigated devices. At the nasopharynx, Spray-sol nebulization covers a surface significantly greater than other devices.
Compared to traditional sprays, Spray-sol and MAD nasal provided a more effective method of delivering topical agents to the deeper and higher portions of the nasal cavities.
CITATION Biomed Res Int. 2019 Mar 28;2019:4602651. doi: 10.1155/2019/4602651