NADPH oxidase CYBA polymorphisms, oxidative stress and cardiovascular diseases
San José G, Fortuño A, Beloqui O, Díez J, Zalba G.
Division of Cardiovascular Sciences, Centre for Applied Medical Research, School of Medicine, University of Navarra, 31008 Pamplona, Spain
Magazine: Clinical Science
Date: Feb 1, 2008Unidad de Chequeos [SP] Cardiology
Oxidative stress plays a key role in the pathophysiology of several major cardiovascular diseases, including atherosclerosis, hypertension, heart failure, stroke and diabetes. ROS (reactive oxygen species) affect multiple tissues either directly or through NO depletion.
ROS induce cardiovascular dysfunction by modulating cell contraction/dilation, migration, growth/apoptosis and extracellular matrix protein turnover, which contribute to vascular and cardiac remodelling. Of the several sources of ROS within the cardiovascular system, a family of multisubunit NADPH oxidases appears to be a predominant contributor of superoxide anion. Recent findings suggest a significant role of the genetic background in NADPH oxidase regulation. Common genetic polymorphisms within the promoter and exonic sequences of CYBA, the gene that encodes the p22(phox) subunit of NADPH oxidase, have been characterized in the context of cardiovascular diseases.
This review aims to present the current state of research into these polymorphisms in their relationship to cardiovascular diseases.
CITATION Clin Sci (Lond). 2008 Feb;114(3):173-82
you maybe interested
The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.
The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.
Learn why we are different from other healthcare centers. Quality, speed, comfort and results.