Multivariate analysis of local response to preoperative treatment in patients with infiltrating carcinoma of the bladder
De Castro F, Robles JE, Agüera L, Rosell D, Abad JI, Berián JM.
Departamento de Urología, Facultad de Medicina, Universidad de Navarra
The article presents a multivariate study carried out by means of a logistic regression of local responses (reduction to stage p0, p1 or p 'in situ') in 82 patients with transitional infiltrant carcinoma of the bladder, undergoing 3 different types of radical therapy: 25 patients treated with TUR and radical cystectomy; 33 patients treated with TUR, pre-operative radiotherapy (45-60 Gy) and radical cystectomy; and 24 patients treated with TUR, intra-operative radiotherapy (15 Gy), external radiotherapy (46 Gy), neo-adjuvant chemotherapy and radical cystectomy. Local response increased with the intensity of pre-operative therapy, there being a better relationship with this approach than with the initial clinical stage of the tumour.
The factors which better explain the prospect of an objective local response are the use of radiotherapy associated to chemotherapy and the absence of metastatic lymphatic nodes. These 2 variables can adequately predict the local response in 87% of patients.
CITATION Actas Urol Esp. 1993 May;17(5):305-9