Linezolid-induced lactic acidosis in two liver transplant patients with the mitochondrial DNA A2706G polymorphism

May 5, 2014 | Magazine: Antimicrobial Agents and Chemotherapy

Del Pozo JL (1), Fernández-Ros N (2), Sáez E (3), Herrero JI (4), Yuste JR (2), Banales JM (5).

ABSTRACT

Mitochondrial toxicity has been recently suggested to be the underlying mechanism of long-term linezolid-associated toxicity in patients with 16S rRNA genetic polymorphisms.

Here, we report for the first time two cases of lactic acidosis due to long-term linezolid exposure in liver transplant recipients who presented an A2706G mitochondrial DNA polymorphism.

CITATION Antimicrob Agents Chemother. 2014 Jul;58(7):4227-9. doi: 10.1128/AAC.02856-14. Epub 2014 May 5.

see publication in pubmed