Scientific publications

Levodopa-induced dyskinesias in Parkinson's disease

Jose A. Obeso (1), Marcelo Merello (2), Maria C. Rodríguez-Oroz (1), Concepció Marin (3), Jorge Guridi (1), and Lazaro Alvarez (4)
(1) Department of Neurology and Neurosurgery, University Clinic and Medical School and Neuroscience Division, University of Navarra and CIMA, Pamplona, Spain
(2) Movement Disorders Section, Raul Carrea Institute for Neurological Research, FLENI, Buenos Aires, Argentina
(3) Laboratori de Neurologia Experimental, Fundació Clínic-Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain
(4) Movement Disorders Unit, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba

Magazine: Handbook of Clinical Neurology

Date: Dec 1, 2007

Neurosurgery Department Neurology [SP]

Hyperkinetic or dyskinetic disorders are characterized by excessive motor activity that interferes with normal motor control mechanism.

The early literature during the 1950s and 1960s used the term ‘hyperkinesia’ to designate wild involuntary movements like chorea, ballism, choreoathetosis or action tremor, all of which are currently embraced under the global denomination of dyskinesias This comprises chorea and ballism, dystonic movements and postures, myoclonus, tics and tremor.

The capacity for levodopa to induce involuntary movements (i.e. levodopa-induced dyskinesias or LID) never witnessed before in Parkinson’s disease (PD) patients was established soon after its introduction in the early 1970s.

CITATION Handb Clin Neurol. 2007;84:185-218

you maybe interested


The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra


Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra