Scientific publications
Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor
Lorenzo-Betancor O, García-Martín E, Cervantes S, Agúndez JA, Jiménez-Jiménez FJ, Alonso-Navarro H, Luengo A, Coria F, Lorenzo E, Irigoyen J, Pastor P.
Background
Essential tremor (ET) is a frequent movement disorder with a substantial family aggregation. A genome-wide association study has recently shown that LINGO1 gene variants are associated with increased risk of ET.
Methods
We intended to replicate these findings by genotyping rs9652490 and rs11856808 in a series of 226 familial ET subjects and 1117 healthy controls from referral movement disorder clinics in Spain.
Results
We were unable to replicate the association between LINGO1 variants and familial ET.
Conclusions
Our results indicate that the LINGO1 variants analyzed are not a major risk factor for developing familial ET in our population, which suggests the existence of other unknown genetic risk factors responsible for familial ET in the Spanish population.
CITATION Eur J Neurol. 2010 Nov 18. doi: 10.1111/j.1468-331.2010.03251