Scientific publications

Involvement of serum vascular endothelial growth factor family members in the development of obesity in mice and humans.

Javier Gómez-Ambrosi (a, b), Victoria Catalán (b), Amaia Rodríguez (a, b), Beatriz Ramírez (a, b), Camilo Silva (b, c), María J. Gil (b, d), Javier Salvador (b, c) and Gema Frühbeck (a, b, c).
(a) Metabolic Research Laboratory, Clínica Universitaria de Navarra, University of Navarra, 31008 Pamplona, Spain
(b) CIBER Fisiopatología de la Obesidad y Nutrición, ISCIII, Spain
(c) Department of Endocrinology, Clínica Universitaria de Navarra, 31008 Pamplona, Spain
(d) Department of Biochemistry, Clínica Universitaria de Navarra, 31008 Pamplona, Spain  

Magazine: The Journal of Nutritional Biochemistry

Date: Jul 16, 2009

Biochemistry [SP] Obesity Unit Endocrinology and Nutrition [SP]

Adipose tissue is highly vascularized implying that angiogenesis takes place in its expansion.

The aim of this study was to compare the concentrations of members of the vascular endothelial growth factor (VEGF) family in obesity. Serum concentrations of VEGFs were analyzed in 15 lean (BMI 20.3±2.5 kg/m2) and 24 obese (BMI 47.6±5.9 kg/m2) volunteers. Obese patients showed significantly increased circulating VEGF-A (150±104 vs. 296±160 pg/ml; P<.05), VEGF-B (2788±1038 vs. 4609±2202 arbitrary units; P<.05) and VEGF-C (13 453±5750 vs. 17 635±5117 pg/ml; P<.05) concentrations. Interestingly, levels of VEGF-D were reduced in obese individuals (538±301 vs. 270±122 pg/ml; P<.01). In addition, VEGF-A significantly decreased after weight loss following Roux-en-Y gastric bypass (BMI from 46.0±8.0 to 28.9±4.2 kg/m2 P<.0001 vs. initial) from 345±229 to 290±216 pg/ml (P<.01). Moreover, in order to corroborate the human findings VEGF-A levels were analyzed during the expansion of adipose tissue in two dynamic models of murine obesity. Serum VEGF-A was significantly increased after 12 weeks on a high-fat diet (43.3±9.0 vs. 29.7±9.1 pg/ml; P<.01) or in ob/ob mice (52.2±18.0 vs. 29.2±7.7 pg/ml; P<.01) and was normalized after leptin replacement in the latter (32.4±14.0 pg/ml; P<.01 vs. untreated ob/ob).

Our data indicates the involvement of these factors in the expansion of adipose tissue that takes place in obesity in relation to the need for increased vascularization, suggesting that manipulation of the VEGF system may represent a potential target for the pharmacological treatment of obesity.

CITATION J Nutr Biochem. 2010 Aug;21(8):774-80

you maybe interested


The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra


Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra