Scientific publications

iNOS Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient ob/ob Mice

Feb 27, 2019 | Magazine: Genes

Becerril S (1,2,3), Rodríguez A (4,5,6), Catalán V (7,8,9), Ramírez B (10,11,12), Unamuno X (13,14,15), Gómez-Ambrosi J (16,17,18), Frühbeck G (19,20,21,22).

ABSTRACT

iNOS deficiency in ob/ob mice improved liver inflammation and ECM remodeling-related genes, decreasing fibrosis, and metabolic dysfunction.

The activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in hepatocytes, suggesting an important role of this alarmin in the development of NAFLD.

CITATION  Genes (Basel). 2019 Feb 27;10(3). pii: E184. doi: 10.3390/genes10030184

see publication in pubmed

Our authors

Dra. Amaia Rodríguez Murueta-Goyena, investigadora del Departamento de Endocrinología
Dr. Amaia Rodríguez Murueta-Goyena [SP] Curriculum
Researcher Endocrinology and Nutrition Department
Navarre headquarters
Imagen de la Dra. Victoria Catalán Goñi, investigadora del Departamento de Endocrinología
Dr. Victoria Catalán Goñi [SP] Curriculum
Researcher Endocrinology and Nutrition Department
Navarre headquarters
Imagen del Dr. Javier Gómez Ambrosi, investigador del Departamento de Endocrinología
Dr. Javier Gómez Ambrosi [SP] Curriculum
Researcher Endocrinology and Nutrition Department
Navarre headquarters
Imagen Gema Frühbeck Martínez, departamento de Endocrinología y Nutrición
Dr. Gema Frühbeck Martínez Curriculum
Researcher Endocrinology and Nutrition Department
Navarre headquarters