iNOS Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient ob/ob Mice

Feb 27, 2019 | Magazine: Genes

Becerril S (1,2,3), Rodríguez A (4,5,6), Catalán V (7,8,9), Ramírez B (10,11,12), Unamuno X (13,14,15), Gómez-Ambrosi J (16,17,18), Frühbeck G (19,20,21,22).

ABSTRACT

iNOS deficiency in ob/ob mice improved liver inflammation and ECM remodeling-related genes, decreasing fibrosis, and metabolic dysfunction.

The activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in hepatocytes, suggesting an important role of this alarmin in the development of NAFLD.

CITATION Genes (Basel). 2019 Feb 27;10(3). pii: E184. doi: 10.3390/genes10030184

see publication in pubmed