Scientific publications

Influence of seasonal variations on histamine release and other immunological parameters in pollinosis.

Diéguez I, Sanz ML, Oehling A.
Departamento de Alergología e Inmunología Clínica, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona, Spain

Magazine: Journal Investigational Allergology and Clinical Immunology

Date: Apr 1, 1991

Allergology and Immunology Department

One hundred and fifty-six pollen-sensitive patients with sensitization to grass pollen only were chosen for this study; 65 patients were allergic to Dermatophagoides, while 45 were non-allergic subjects with no atopic history.

The following tests were carried out on all patients: histamine release of total blood, basal histamine, total histamine, determination of total IgE and specific IgE (RAST) serum levels, serum hemagglutinating antibodies and skin tests. Seasonal increase of IgE was observed, with post-seasonal fall; 50% of the cases reached normal values. However, RAST as a semiquantitative method did not prove to be useful in the detection of variations in specific IgE levels.

During pollination, an increase in titers in pollen-sensitive subjects was seen. This was attributed to a humoral immune response epiphenomenon which was independent of IgE. The histamine release test was significantly greater during pollination in pollen-sensitive subjects. The total of stored histamine increased during the months of allergenic exposure.

CITATION J Investig Allergol Clin Immunol. 1991 Apr;1(2):101-8

you maybe interested


The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra


Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra