Scientific publications

Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation

Feb 25, 2021 | Magazine: Frontiers in Cardiovascular Medicine

María Dolores García-Cosío  1   2 , Francisco González-Vilchez  3 , Raquel López-Vilella  4 , Eduardo Barge-Caballero  2   5 , Manuel Gómez Bueno  2   6 , Manuel Martínez-Selles  2   7 , Jose María Arizón  8 , Diego Rangel Sousa  9 , José González-Costello  10 , Sonia Mirabet  11 , Félix Pérez-Villa  12 , Beatriz Díaz Molina  13 , Gregorio Rábago  14 , Ana Portolés Ocampo  15 , Luis de la Fuente Galán  16 , Iris Garrido  17 , Juan F Delgado  1   2   18


Biological differences between males and females change the course of different diseases and affect therapeutic measures' responses. Heart failure is not an exception to these differences.

Women account for a minority of patients on the waiting list for heart transplantation or other advanced heart failure therapies. The reason for this under-representation is unknown. Men have a worse cardiovascular risk profile and suffer more often from ischemic heart disease.

Conversely, transplanted women are younger and more frequently have non-ischemic cardiac disorders. Women's poorer survival on the waiting list for heart transplantation has been previously described, but this trend has been corrected in recent years.

The use of ventricular assist devices in women is progressively increasing, with comparable results than in men. The indication rate for a heart transplant in women (number of women on the waiting list for millions of habitants) has remained unchanged over the past 25 years. Long-term results of heart transplants are equal for both men and women.

We have analyzed the data of a national registry of heart transplant patients to look for possible future directions for a more in-depth study of sex differences in this area. We have analyzed 1-year outcomes of heart transplant recipients. We found similar results in men and women and no sex-related interactions with any of the factors related to survival or differences in death causes between men and women.

We should keep trying to approach sex differences in prospective studies to confirm if they deserve a different approach, which is not supported by current evidence.

CITATION  Front Cardiovasc Med. 2021 Feb 25;8:630113.  doi: 10.3389/fcvm.2021.630113.  eCollection 2021