In Vitro Model for Simulating Drug Delivery during Balloon-Occluded Transarterial Chemoembolization
Jorge Aramburu 1 , Raúl Antón 1 2 , Junichi Fukamizu 3 , Daiki Nozawa 3 , Makoto Takahashi 4 , Kouji Ozaki 4 , Juan Carlos Ramos 1 , Bruno Sangro 2 5 , José Ignacio Bilbao 2 6 , Kosuke Tomita 7 , Tomohiro Matsumoto 7 , Terumitsu Hasebe 7
Background: Balloon-occluded transarterial chemoembolization (B-TACE) has emerged as a safe and effective procedure for patients with liver cancer, which is one of the deadliest types of cancer worldwide. B-TACE consist of the transcatheter intraarterial infusion of chemotherapeutic agents, followed by embolizing particles, and it is performed with a microballoon catheter that temporarily occludes a hepatic artery.
B-TACE relies on the blood flow redistribution promoted by the balloon-occlusion. However, flow redistribution phenomenon is not yet well understood.
Methods: This study aims to present a simple in vitro model (IVM) where B-TACE can be simulated.
Results: By visually analyzing the results of various clinically-realistic experiments, the IVM allows for the understanding of balloon-occlusion-related hemodynamic changes and the importance of the occlusion site.
Conclusion: The IVM can be used as an educational tool to help clinicians better understand B-TACE treatments. This IVM could also serve as a base for a more sophisticated IVM to be used as a research tool.
CITATION Biology (Basel). 2021 Dec 16;10(12):1341. doi: 10.3390/biology10121341