Scientific publications

In Vitro Model for Simulating Drug Delivery during Balloon-Occluded Transarterial Chemoembolization

Dec 16, 2021 | Magazine: Biology

Jorge Aramburu  1 , Raúl Antón  1   2 , Junichi Fukamizu  3 , Daiki Nozawa  3 , Makoto Takahashi  4 , Kouji Ozaki  4 , Juan Carlos Ramos  1 , Bruno Sangro  2   5 , José Ignacio Bilbao  2   6 , Kosuke Tomita  7 , Tomohiro Matsumoto  7 , Terumitsu Hasebe  7

Background: Balloon-occluded transarterial chemoembolization (B-TACE) has emerged as a safe and effective procedure for patients with liver cancer, which is one of the deadliest types of cancer worldwide. B-TACE consist of the transcatheter intraarterial infusion of chemotherapeutic agents, followed by embolizing particles, and it is performed with a microballoon catheter that temporarily occludes a hepatic artery.

B-TACE relies on the blood flow redistribution promoted by the balloon-occlusion. However, flow redistribution phenomenon is not yet well understood.

Methods: This study aims to present a simple in vitro model (IVM) where B-TACE can be simulated.

Results: By visually analyzing the results of various clinically-realistic experiments, the IVM allows for the understanding of balloon-occlusion-related hemodynamic changes and the importance of the occlusion site.

Conclusion: The IVM can be used as an educational tool to help clinicians better understand B-TACE treatments. This IVM could also serve as a base for a more sophisticated IVM to be used as a research tool.

CITATION  Biology (Basel). 2021 Dec 16;10(12):1341.  doi: 10.3390/biology10121341

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