Scientific publications

Impact of adipokines and myokines on fat browning

Mar 31, 2020 | Magazine: Journal of Physiology and Biochemistry

Rodríguez A (1,2,3), Catalán V (1,2,3), Ramírez B (1,2,3), Unamuno X (1,2,4), Portincasa P (5), Gómez-Ambrosi J (1,2,3), Frühbeck G (1,2,3,6), Becerril S (7,8,9).

Since the discovery of leptin in 1994, the adipose tissue (AT) is not just considered a passive fat storage organ but also an extremely active secretory and endocrine organ that secretes a large variety of hormones, called adipokines, involved in energy metabolism.

Adipokines may not only contribute to AT dysfunction and obesity, but also in fat browning, a process that induces a phenotypic switch from energy-storing white adipocytes to thermogenic brown fat-like cells. The fat browning process and, consequently, thermogenesis can also be stimulated by physical exercise.

Contracting skeletal muscle is a metabolically active tissue that participates in several endocrine functions through the production of bioactive factors, collectively termed myokines, proposed as the mediators of physical activity-induced health benefits. Myokines affect muscle mass, have profound effects on glucose and lipid metabolism, and promote browning and thermogenesis of white AT in an endocrine and/or paracrine manner.

The present review focuses on the role of different myokines and adipokines in the regulation of fat browning, as well as in the potential cross-talk between AT and skeletal muscle, in order to control body weight, energy expenditure and thermogenesis.

CITA DEL ARTÍCULO  J Physiol Biochem. 2020 Mar 31. doi: 10.1007/s13105-020-00736-2.