Hours
How to get here
Upon arrival
When departing

Quotes and payment methods
ACUNSA Insurance
Other insurance companies

Obtain a remote medical opinion for your clinical case, from your home and without travelling, with the quality and support of the Clínica Universidad de Navarra.

Request a Second Opinion

If you want us to contact you, tell us your phone number and we will call you.

I accept the Terms and conditions, and the Data protection policy

Please indicate when you would prefer that we call you:

Any time Morning (9:00 - 12:00) * Midday (12:00 - 16:00) * Afternoon (16:00 - 21:00) *

* Operating hours based on Spanish (Peninsula) time.

Thank you. We will be in touch shortly.

The Phone no. field is required.

Please review the phone no. indicated, which must contain 9-15 digits and begin with 6,8,9,71,72,73 or 74. For international numbers please indicate 00, followed by the international country code, followed by the phone number.

You must accept Terms and conditions, and the Data protection policy.

Wait a few moments while we process your request.

Close Submit

Av. Pío XII, 36
31008. Pamplona (Navarra), España Contact us

patient area

Headquarters in Madrid

make an appointment

DISEASES
AND TREATMENTS
- We are an international leader in highly specialized procedures.
CHECK-UPS
AND HEALTH
- - MEDICAL CHECK-UPS
  - SPORTS CHECK
  Prevention constitutes the best way to enjoy a longer and healthier life.
ABOUT
US
- Our objective is to offer the patient the best possible medical and human treatment.
OUR
PROFESSIONALS
- - MEDICAL SERVICES
  - DOCTORS & MEDICAL STAFF
  Speed and effectiveness in admission, diagnosis and access to treatment.
RESEARCH&TRIALS
- - CLINICAL TRIALS
  - SCIENTIFIC PUBLICATIONS
  We are the private Spanish medical facility conducting the most clinical trials.
INTERNATIONAL
PATIENTS

IgG4 blocking effect on the release of antigen-specific histamine

García BE, Sanz ML, Gato JJ, Fernández J, Oehling A.
Department of Allergology and Clinical Immunology, Faculty of Medicine, University of Navarra, Pamplona, Spain

Magazine: Journal Investigational Allergology and Clinical Immunology

Date: Feb 1, 1993

Allergology and Immunology Department

We evaluated the biological effect of IgG4 antibodies in pollinosis. We studied the ability of IgG4 to mediate histamine release by measuring anti-IgG4 in pollinic patients without previous immunotherapy. We also evaluated the modifications that sera rich in specific IgG4 and IgG itself exert upon antigen-specific histamine release.

According to our results, stimulation with anti-IgG4 did not induce histamine release, as opposed to stimulation with anti-IgE, which induced histamine release in all the cases studied. On the other hand, hyperimmune sera from pollinic subjects under immunotherapy and with high levels of specific IgG4 significantly inhibited the release of antigen-specific histamine from basophils of untreated patients.

After isolating IgG4 by means of affinity chromatography, preincubation of this fraction with the allergen gave rise to a significant reduction in histamine release compared to preincubation of the antigen with normal sera.

CITATION J Investig Allergol Clin Immunol. 1993 Jan-Feb;3(1):26-33

you maybe interested

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra