Scientific publications

Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients

A. Campo (1), G. Frühbeck (2), J.J. Zulueta (1), J. Iriarte (3), L.M. Seijo (1), A.B. Alcaide (1), J.B. Galdiz (4) and J. Salvador (2)
Depts of (1) Pulmonary Medicine, (2) Endocrinology, and (3) Neurophysiology, Clinica Universitaria de Navarra, University of Navarra, Pamplona
(4) Dept of Pulmonary Medicine, Hospital de Cruces, Vizcaya, Spain

Magazine: The European Respiratory Journal

Date: Aug 1, 2007

Endocrinology and Nutrition [SP] Neurophysiology [SP] Pneumology

Leptin is a powerful stimulant of ventilation in rodents. In humans, resistance to leptin has been consistently associated with obesity.

Raised leptin levels have been reported in subjects with sleep apnoea or obesity–hypoventilation syndrome. The aim of the present study was to assess, by multivariate analysis, the possible association between respiratory centre impairment and levels of serum leptin. In total, 364 obese subjects (body mass index o30 kg?m-2) underwent the following tests: sleep studies, respiratory function tests, baseline and hypercapnic response (mouth occlusion pressure (P0.1), minute ventilation), fasting leptin levels, body composition and anthropometric measures. Subjects with airways obstruction on spirometry were excluded.

Out of the 346 subjects undergoing testing, 245 were included in the current analysis. Lung volumes, age, log leptin levels, end-tidal carbon dioxide tension, percentage body fat and minimal nocturnal saturation were predictors for baseline P0.1. The hypercapnic response test was performed by 186 subjects; log leptin levels were predictors for hypercapnic response in males, but not in females. Hyperleptinaemia is associated with a reduction in respiratory drive and hypercapnic response, irrespective of the amount of body fat.

These data suggest the extension of leptin resistance to the respiratory centre.

CITATION  Eur Respir J. 2007 Aug;30(2):223-31

you maybe interested


The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra


Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra