Scientific publications

Home-based transcranial static magnetic field stimulation of the motor cortex for treating levodopa-induced dyskinesias in Parkinson's disease: A randomized controlled trial

May 21, 2022 | Magazine: Brain Stimulation

Michele Dileone  1 , Claudia Ammann  2 , Valentina Catanzaro  2 , Cristina Pagge  3 , Rosanna Piredda  2 , Mariana H G Monje  4 , Irene Navalpotro-Gomez  5 , Alberto Bergareche  5 , María Cruz Rodríguez-Oroz  6 , Lydia Vela-Desojo  7 , Fernando Alonso-Frech  8 , María J Catalán  9 , José A Molina  10 , Nuria López-Ariztegu  11 , Antonio Oliviero  12 , José A Obeso  13 , Guglielmo Foffani  14

Dear Editor,

Levodopa-induced dyskinesias are a common complication in patients with Parkinson's disease (PD) treated chronically with levodopa. Even though dyskinesias may be more tolerable than parkinsonism, they can be highly debilitating for some patients. The difficulty to achieve satisfactory pharmacological treatment of dyskinesias often motivates the escalation toward more advanced invasive treatments. However, even with invasive treatments dyskinesias may remain problematic.

A promising approach is offered by non-invasive brain stimulation (NIBS). Several small, randomized studies (sample sizes ≤17 patients) suggest that presumably reducing the excitability of motor cortical areas with repetitive transcranial magnetic stimulation (rTMS) may be effective for reducing levodopa-induced dyskinesias [1]. However, rTMS is not portable, which limits its application to a center-based therapeutic model and possibly hindered the path toward larger, longer and more definitive clinical trials.

CITATION  Brain Stimul. 2022 May 21;S1935-861X(22)00091-2. doi: 10.1016/j.brs.2022.05.012

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