Scientific publications

HLA-DR2 and white matter lesion distribution in multiple sclerosis

Sepulcre J, Masdeu JC, Palacios R, Goñi J, Moreno B, Tainta M, Bejarano B, Villoslada P.
Department of Neurology and Neurosurgery of the Clínica Universitaria de Navarra, Pamplona, Spain.

Magazine: Journal of Neuroimaging

Date: Jul 1, 2008

Neurosurgery Department

Human leukocyte antigen DR2 (HLA-DR2) is a well-established genetic risk factor for multiple sclerosis (MS). However, it is still unknown whether this factor is associated with a specific disease phenotype, and in particular, to a regional distribution of white matter (WM) lesion phenotype on magnetic resonance imaging (MRI).

On a voxel-by-voxel basis, we analyzed the T1 and T2 MRI-derived lesion maps of 50 patients with MS in order to determine the possible influence of HLA-DR2 genotype on the lesional MRI pattern at early stages of the disease. HLA-DR2 was present in 15 (30%) patients of our cohort. They displayed similar WM lesion distribution as the subjects without this factor. Thus, lesion distribution in MS seems to be independent of the DR2 genotype.

CITATION  J Neuroimaging. 2008 Jul;18(3):328-31

you maybe interested


The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra


The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra


Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra