High serum cholesterol levels are associated with herpes zoster infection after heart transplantation
Jose L Del Pozo,1,7 Diederik van de Beek,1,2,8 Jayawant N. Mandrekar,3 Richard C. Daly,4,5 Christopher G.A. McGregor,4 Jose R Azanza,7 and Robin Patel1,6
1Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
2Division of Critical Care Neurology, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
3Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA
4Division of Cardiovascular Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA
5Division of Cardiovascular Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
6Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
7Infectious Diseases Division. Clínica Universidad de Navarra. Pamplona, Spain
8Department of Neurology, Center of Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Amsterdam, The Netherlands
Magazine: Clinical Infectious Diseases
Date: Jan 1, 2010Clinical Pharmacology [SP] Clinical Microbiology [SP] Infectious Diseases [SP]
Sun and Singh reported that statins might improve morbidity and mortality attributable to sepsis or infection in organ transplant recipients. Statins have antiviral effects against HIV-1, BK virus, cytomegalovirus, Epstein-Barr virus and hepatitis C. Cholesterol is required for varicella zoster virus (VZV) cell entry. The relationship between cholesterol serum levels and risk of VZV post-transplant infection, if any, is unknown. We performed a case-control analysis to test the hypothesis that serum cholesterol is associated with an increased risk of zoster in heart transplant patients.
CITATION Clin Infect Dis. 2010 Jan 1;50(1):121-2.
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