High frequency stimulation of the subthalamic nucleus and levodopa induced dyskinesias in Parkinson's disease
Obeso J.A., Linazasoro G., Guridi J., Ramos E., Rodríguez-Oroz M.C.
Clínica Universidad de Navarra, Pamplona, España
Reduction in the neuronal activity of the subthalamic nucleus leading to diminished excitation of the globus pallidum internum is associated with chorea-ballism in monkeys.
Levodopa induced dyskinesias are currently thought to share a similar pathophysiology but recent findings also suggest that abnormal patterns of neuronal firing in the globus pallidum internum may be as relevant.
Data from both parkinsonian monkeys and patients with Parkinson's disease submitted to lesion or functional blockade of the subthalamic nucleus are in keeping with such a general principle, but the threshold to induce dyskinesias in the parkinsonian state is higher than in intact animals.
CITATION J Neurol Neurosurg Psychiatry. 2000 Jan;68(1):122-3