Scientific publications

High-frequency oscillations in the somatosensory evoked potentials of patients with cortical myoclonus: pathophysiologic implications

Alegre M., Urriza J., Valencia M., Muruzábal J., Iriarte J., Artieda J.
Clinical Neurophysiology Section, Department of Neurology, Clínica Universitaria, Universidad de Navarra, Pamplona, Spain.

Magazine: Journal of Clinical Neurophysiology

Date: Jun 1, 2006

Neurophysiology [SP]

A small series of high-frequency wavelets overlapping the earliest part of the N20 wave (high-frequency oscillations, HFOs) can be observed in the somatosensory evoked potentials (SSEPs) of normal subjects after filtering then with a high-pass filter (>500 Hz).

These HFOs have been related to interneuronal activity in the primary somatosensory cortex. In patients with cortical myoclonus there is a sensorimotor cortical hyperexcitability, expressed neurophysiologically as high-amplitude waves in the SSEPs (giant SSEPs). There have been contradicting reports in the literature on the changes in the HFOs in these patients. The authors studied HFOs in a group of 20 patients with cortical myoclonus of different origins and in a control group by means of time-frequency transforms, comparing the results obtained with the amplitude and latency of the classical SSEP waves. All controls had normal HFOs, with two components. Nine patients had no HFOs, nine patients had low-amplitude and/or delayed HFOs, and the remaining two patients, the only without ataxia, had high-amplitude HFOs with a long latency.

These results suggest heterogeneity in the pathophysiology of cortical myoclonus, which might be related to the different systems affected.

CITATION  J Clin Neurophysiol. 2006 Jun;23(3):265-72

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