High-dose daptomycin is effective as an antibiotic-lock therapy in a rabbit model of Staphylococcus epidermidis catheter-related infection
Basas J (1), Palau M (1), Ratia C (1), Luis Del Pozo J (2), Martín-Gómez MT 3, Gomis X (1), Torrents E (4), Almirante B (1), Gavaldà J (5).
(1) Antimicrobial Resistance Laboratory, Vall d'Hebron Research Institute (VHIR). Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
(2) Infectious Disease Division, Internal Medicine Department, Clínica Universitaria de Navarra, Navarra, Spain.
(3) Microbiology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
(4) Institute for Bioengineering of Catalonia (IBEC), Bacterial Infections and Antimicrobial Therapies, Barcelona, Spain.
(5) Antimicrobial Resistance Laboratory, Vall d'Hebron Research Institute (VHIR). Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Magazine: Antimicrobial Agents Chemotherapy
Date: Nov 20, 2017Infectious Diseases [SP] Clinical Microbiology [SP]
Long-term catheter-related bloodstream infections (CRBSI) involving coagulase-negative Staphylococci are associated with poor patient outcomes, increased hospitalization and high treatment costs.
The use of vancomycin-lock therapy has been an important step forward to treat these biofilms although failures appear in 20% of patients. In this study, we report that a high dose of daptomycin-lock therapy may offer a therapeutic advantage for these CRBSI in just 24 h of treatment.
CITATION Antimicrob Agents Chemother. 2017 Nov 20. pii: AAC.01777-17. doi: 10.1128/AAC.01777-17
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