Scientific publications

High-dose daptomycin is effective as an antibiotic-lock therapy in a rabbit model of Staphylococcus epidermidis catheter-related infection

Jan 1, 2018 | Magazine: Antimicrobial Agents Chemotherapy

Basas J (1), Palau M (1), Ratia C (1), Luis Del Pozo J (2), Martín-Gómez MT 3, Gomis X (1), Torrents E (4), Almirante B (1), Gavaldà J (5).


Long-term catheter-related bloodstream infections (CRBSI) involving coagulase-negative Staphylococci are associated with poor patient outcomes, increased hospitalization and high treatment costs.

The use of vancomycin-lock therapy has been an important step forward to treat these biofilms although failures appear in 20% of patients. In this study, we report that a high dose of daptomycin-lock therapy may offer a therapeutic advantage for these CRBSI in just 24 h of treatment.

CITATION  Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01777-17.  doi: 10.1128/AAC.01777-17. Print 2018 Feb.