Guidelines for diagnosis, prevention and management of central nervous system involvement in diffuse large B-cell lymphoma patients by the Spanish Lymphoma Group (GELTAMO)
Peñalver FJ (1), Sancho JM (2), de la Fuente A (3), Olave MT (4), Martin A (5), Panizo C (6), Pérez E (7), Salar A (8), Orfao A (9).
(1) Department of Hematology, Hospital Universitario Fundacion Alcorcon, Alcorcon, Madrid, Spain.
(2) Clinical Hematology Department, ICO-IJC Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain.
(3) Department of Hematology, MD Anderson Cancer Center, Madrid, Spain.
(4) Department of Hematology, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain.
(5) Department of Hematology, Hospital Universitario de Salamanca and IBSAL, Salamanca, Spain.
(6) Department of Hematology, Clinica Universidad de Navarra, Pamplona, Spain.
(7) Department of Hematology, Hospital General Universitario Morales Meseguer, Murcia, Spain.
(8) Department of Hematology, Hospital del Mar, Barcelona, Spain.
(9) Department of Hematology, Hospital Universitario de Salamanca.
Diffuse large B-cell lymphoma patients have a 5% overall risk of central nervous system events (relapse or progression), which account for high morbidity and frequently fatal outcomes1 and shortened overall survival of <6 months.
Early diagnosis of central nervous system events is critical for successful treatment and improved prognosis. Identification of patients at risk of central nervous system disease is critical to accurately identify candidates for central nervous system- prophylaxis vs.
35 This report by the Spanish Lymphoma Group (GELTAMO) aims to provide useful guidelines and recommendations for the prevention, diagnosis, and treatment of central nervous system diffuse large B-cell lymphoma patients with (or at risk of) leptomeningeal and/or brain parenchyma lymphoma relapse.
A panel of lymphoma experts working on behalf of GELTAMO reviewed all data published on these topics available in PubMed up to May 2016. Recommendations were classified according to the Grading of Recommendations Assessment Development and Evaluation (GRADE) approach.
Then, a practical algorithm based on the proposed recommendations was developed (Figure 1). Initial discussions among experts were held in May 2014 and final consensus was reached in June 2016. The final manuscript was reviewed by all authors and the Scientific Committee of GELTAMO.
CITATION Haematologica. 2016 Oct 20. pii: haematol.2016.149120